Phenotypes Associated with This Genotype

Genotype
MGI:5563353

• Allelic Composition: Cd72^c/Cd72^c; Fas^lpr/Fas^lpr
• Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased spleen weight ( J:204782 )

• at 12 months compared with Fas^lpr homozygotes on a C57BL/6 background

abnormal B cell number ( J:204782 )

• reduced percentage compared with Fas^lpr homozygotes on a C57BL/6 background

abnormal T cell number ( J:204782 )

• increased percentage compared with Fas^lpr homozygotes on a C57BL/6 background

• however, the percentage of B220+CD3+ T cells is the same as in Fas^lpr homozygotes on a C57BL/6 background

increased IgG level ( J:204782 )

• compared with Fas^lpr homozygotes on a C57BL/6 background

enlarged lymph nodes ( J:204782 )

• moderate at 12 months compared with Fas^lpr homozygotes on a C57BL/6 background

autoimmune response ( J:204782 )

increased susceptibility to systemic lupus erythematosus ( J:204782 )

• more severe lupus-like disease (greater increase in spleen weight, lymphadenopathy, reduced percentage of B cells, increased percentage of T cells, increased inflammation in the lungs and liver, more severe glomerular lesions and increased nuclear autoantibodies) compared with Fas^lpr homozygotes on a C57BL/6 background

increased anti-chromatin antibody level ( J:204782 )

• at 12 months compared with Fas^lpr homozygotes on a C57BL/6 background

increased anti-double stranded DNA antibody level ( J:204782 )

increased anti-single stranded DNA antibody level ( J:204782 )

• at 12 months compared with Fas^lpr homozygotes on a C57BL/6 background

• however, levels are lower than in Fas^lpr homozygotes on an MRL background

liver inflammation ( J:204782 )

• mice exhibit more severe cell infiltration in the lung and liver compared with Fas^lpr homozygotes on a C57BL/6 background

lung inflammation ( J:204782 )

• mice exhibit more severe cell infiltration in the lung and liver compared with Fas^lpr homozygotes on a C57BL/6 background

renal/urinary system

cortical renal glomerulopathies ( J:204782 )

• more severe glomerular lesions with more prominent immune complex deposition compared with Fas^lpr homozygotes on a C57BL/6 background

liver/biliary system

liver inflammation ( J:204782 )

• mice exhibit more severe cell infiltration in the lung and liver compared with Fas^lpr homozygotes on a C57BL/6 background

respiratory system

lung inflammation ( J:204782 )

• mice exhibit more severe cell infiltration in the lung and liver compared with Fas^lpr homozygotes on a C57BL/6 background

hematopoietic system

increased spleen weight ( J:204782 )

• at 12 months compared with Fas^lpr homozygotes on a C57BL/6 background

abnormal B cell number ( J:204782 )

• reduced percentage compared with Fas^lpr homozygotes on a C57BL/6 background

abnormal T cell number ( J:204782 )

• increased percentage compared with Fas^lpr homozygotes on a C57BL/6 background

• however, the percentage of B220+CD3+ T cells is the same as in Fas^lpr homozygotes on a C57BL/6 background

increased IgG level ( J:204782 )

• compared with Fas^lpr homozygotes on a C57BL/6 background

growth/size/body

increased spleen weight ( J:204782 )

• at 12 months compared with Fas^lpr homozygotes on a C57BL/6 background