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Phenotypes Associated with This Genotype
Genotype
MGI:5564914
Allelic
Composition
Bcl11atm1Pwt/Bcl11atm1Pwt
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Pwt mutation (0 available); any Bcl11a mutation (44 available)
Commd10Tg(Vav1-icre)A2Kio mutation (4 available); any Commd10 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• granulocytes, T cells, macrophage conventional dendritic cells and dendritic cell progenitors not affected in spleen and bone marrow
• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• also reduced in the spleen but not as severely as in the bone marrow
• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• proportionate to the loss of plasmacytoid dendritic cell in bone marrow and spleen
• about a 2-fold decrease in the bone marrow

immune system
• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• also reduced in the spleen but not as severely as in the bone marrow
• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• proportionate to the loss of plasmacytoid dendritic cell in bone marrow and spleen
• following infection with human HSV strain 17

homeostasis/metabolism
• following infection with human HSV strain 17


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory