Phenotypes Associated with This Genotype

Genotype
MGI:5571486

• Allelic Composition: Ahr^tm1.2Arte/Ahr^tm1.2Arte
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

teratozoospermia ( J:210360 )

♂ • flattening of the base of the head, loss of the typical hook-shaped head, changes in the flagellum such as a folded or coiled tail, and the presence of a cytoplasmic droplet

♂ • however, mice exhibit normal sperm count, average motility and progressive motility

coiled sperm flagellum ( J:210360 )

♂ • folded or coiled

abnormal sperm head morphology ( J:210360 )

♂ • flattening of the base of the head and loss of the typical hook-shaped head

multinucleated giant male germ cells ( J:210360 )

♂

abnormal male germ cell apoptosis ( J:210360 )

♂ • in the seminiferous tubules

abnormal seminiferous tubule epithelium morphology ( J:210360 )

♂ • hypocellularity with widened intercellular spaces, multinucleated giant cells and vacuoles

seminiferous tubule degeneration ( J:210360 )

♂ • with increased apoptotic cells

decreased testis weight ( J:210360 )

♂

abnormal spermiation ( J:210360 )

♂ • failure of spermatids to disengage indicated by excess numbers of retained spermatids in the basal compartment of the seminiferous epithelium

abnormal cauda epididymis morphology ( J:210360 )

♂ • decreased weight

decreased epididymis weight ( J:210360 )

♂

decreased fertilization frequency ( J:210360 )

♂ • as determined by in vitro fertilization with increased progression of two-cell embryos to blastocyst-stage embryos

cellular

teratozoospermia ( J:210360 )

♂ • flattening of the base of the head, loss of the typical hook-shaped head, changes in the flagellum such as a folded or coiled tail, and the presence of a cytoplasmic droplet

♂ • however, mice exhibit normal sperm count, average motility and progressive motility

coiled sperm flagellum ( J:210360 )

♂ • folded or coiled

abnormal sperm head morphology ( J:210360 )

♂ • flattening of the base of the head and loss of the typical hook-shaped head

multinucleated giant male germ cells ( J:210360 )

♂

abnormal male germ cell apoptosis ( J:210360 )

♂ • in the seminiferous tubules

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:210360 )

♂ • hypocellularity with widened intercellular spaces, multinucleated giant cells and vacuoles

seminiferous tubule degeneration ( J:210360 )

♂ • with increased apoptotic cells

decreased testis weight ( J:210360 )

♂