Phenotypes Associated with This Genotype

Genotype
MGI:5574445

• Allelic Composition: Nrip1^tm1Mpk/Nrip1^tm1Mpk
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased enterocyte apoptosis ( J:211324 )

• 3-fold

abnormal enterocyte proliferation ( J:211324 )

• 2.6-fold increase in cells synthesizing DNA compared with wild-type mice

digestive/alimentary system

increased enterocyte apoptosis ( J:211324 )

• 3-fold

abnormal enterocyte proliferation ( J:211324 )

• 2.6-fold increase in cells synthesizing DNA compared with wild-type mice

abnormal small intestine morphology ( J:211324 )

• crypt to villus axis is increased compared to in wild-type mice

• higher increase in villi and crypt length following whole body irradiation

• shorter intestine compared with wild-type mice

• however, total surface area of intestinal epithelium is normal

abnormal Paneth cell morphology ( J:211324 )

• increased differentiation

endocrine/exocrine glands

abnormal Paneth cell morphology ( J:211324 )

• increased differentiation

homeostasis/metabolism

abnormal response to injury ( J:211324 )

• following whole body irradiation, mice exhibit increased number of regenerating villi and a higher increase in villi and crypt length compared with in wild-type mice