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Phenotypes Associated with This Genotype
Genotype
MGI:5576973
Allelic
Composition		 Hprt1tm4(CAG-Tbx18*,-Venus)Akis/Y
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Tbx18tm4(cre)Akis/Tbx18+
Genetic
Background		 involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (1024 available)
Hprt1tm4(CAG-Tbx18*,-Venus)Akis mutation (0 available); any Hprt1 mutation (1281 available)
Tbx18tm4(cre)Akis mutation (0 available); any Tbx18 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal epicardium development ( J:210076 )
• epicardial cells exhibit premature smooth muscle cell differentiation and fail to invade into the right ventricular myocardium unlike in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory