Phenotypes for Hprt1 Tbx18 MGI:5576974 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺
Genetic Background	involves: 129S1/SvImJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis} mutation (0 available); any Hprt1 mutation (1281 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:210076 )

• mice die at E14.5

cardiovascular system

cardiovascular system phenotype ( J:210076 )

N	• cardiomyocytes apoptosis and size are normal

abnormal sinus venosus morphology ( J:210076 )

• sinus horn defects

heart hypoplasia ( J:210076 )

thin ventricle myocardium compact layer ( J:210076 )

• beginning at E12.5 and worsening at E14.5

abnormal pericardium morphology ( J:210076 )

decreased fetal cardiomyocyte proliferation ( J:210076 )

• in the right ventricular myocardium at E12.5 and E13.5

cellular

decreased fetal cardiomyocyte proliferation ( J:210076 )

• in the right ventricular myocardium at E12.5 and E13.5

muscle

thin ventricle myocardium compact layer ( J:210076 )

• beginning at E12.5 and worsening at E14.5

decreased fetal cardiomyocyte proliferation ( J:210076 )

• in the right ventricular myocardium at E12.5 and E13.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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