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Phenotypes Associated with This Genotype
Genotype
MGI:5578146
Allelic
Composition		 Rab8atm1.2Aha/Rab8atm1.2Aha
Rab8btm1.2Aha/Rab8btm1.2Aha
Genetic
Background		 involves: BALB/cJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab8atm1.2Aha mutation (0 available); any Rab8a mutation (18 available)
Rab8btm1.2Aha mutation (0 available); any Rab8b mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:211898 )
• mice gradually die 2 weeks after birth

digestive/alimentary system
abnormal small intestinal microvillus morphology ( J:211898 )
• atrophic with inclusions at P14

cellular
cellular phenotype ( J:211898 )
N
• mice exhibit normal length and morphology of cilia on mouse embryonic fibroblasts

respiratory system
respiratory system phenotype ( J:211898 )
N
• mice exhibit normal motile cilia in the trachea

vision/eye
vision/eye phenotype ( J:211898 )
N
• mice exhibit normal motile cilia in the retina

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory