Phenotypes Associated with This Genotype

Genotype
MGI:5578647

• Allelic Composition: Tmprss2^{tm2.1(ETV1)Sho}/Tmprss2^{tm2.1(ETV1)Sho}
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:212219 )

♂N • prostates are largely normal and do not develop prostatic intraepithelial neoplasia (PIN) lesions or cancer

prostate gland inflammation ( J:212219 )

♂ • in 4 of 11 mice

homeostasis/metabolism

abnormal testosterone level ( J:212219 )

♂ • castrated mice exhibit higher levels of testosterone in prostate cells compared with castrated wild-type mice

♂ • however, non-castrated mice exhibit normal testosterone levels

neoplasm

neoplasm ( J:212219 )

♂N • prostates do not develop prostatic intraepithelial neoplasia (PIN) lesions or cancer

immune system

prostate gland inflammation ( J:212219 )

♂ • in 4 of 11 mice

endocrine/exocrine glands

prostate gland inflammation ( J:212219 )

♂ • in 4 of 11 mice