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Phenotypes Associated with This Genotype
Genotype
MGI:5578649
Allelic
Composition		 Ptentm1Hwu/Pten+
Tmprss2tm2.1(ETV1)Sho/Tmprss2tm2.1(ETV1)Sho
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
Tmprss2tm2.1(ETV1)Sho mutation (0 available); any Tmprss2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:212219 )
• most mice die before 1 year of age

reproductive system
increased prostate gland adenocarcinoma incidence ( J:212219 )
• invasive with metastasis into the prostate stroma and urogenital area

neoplasm
increased prostate gland adenocarcinoma incidence ( J:212219 )
• invasive with metastasis into the prostate stroma and urogenital area

endocrine/exocrine glands
increased prostate gland adenocarcinoma incidence ( J:212219 )
• invasive with metastasis into the prostate stroma and urogenital area

growth/size/body
prostate gland cyst ( J:212219 )
• large

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory