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Phenotypes Associated with This Genotype
Genotype
MGI:5581690
Allelic
Composition		 Bhlhe22tm3.1(cre)Meg/Bhlhe22+
Gata3tm1Jfz/Gata3tm2Gsv
Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm3.1(cre)Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Gata3tm1Jfz mutation (0 available); any Gata3 mutation (32 available)
Gata3tm2Gsv mutation (0 available); any Gata3 mutation (32 available)
Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good mutation (0 available); any Gt(ROSA)26Sor mutation (1024 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal inner hair cell synaptic ribbon morphology ( J:207904 )
• partial rescue of ribbon loss observed Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice
abnormal cochlear ganglion morphology ( J:207904 )
• partial rescue of synaptic defects observed Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice

hearing/vestibular/ear
abnormal inner hair cell synaptic ribbon morphology ( J:207904 )
• partial rescue of ribbon loss observed Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory