Phenotypes for Gt(ROSA)26Sor Ptpn11 Tg(Dhh-cre)1Mejr MGI:5588150 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gt(ROSA)26Sor^{tm8(Map2k1*,EGFP)Rsky}/? Ptpn11^tm1.1Wbm/Ptpn11^tm1.1Wbm Tg(Dhh-cre)1Mejr/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm8(Map2k1*,EGFP)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (958 available)
Ptpn11^tm1.1Wbm mutation (1 available); any Ptpn11 mutation (43 available)
Tg(Dhh-cre)1Mejr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

hypermyelination ( J:207470 )

• axons of peripheral nerves are hypermyelinated at P90

• however, mice show normal numbers of Schwann cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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