Analysis Tools
mortality/aging
craniofacial
|
• squamosal bone is slightly hypoplastic
|
|
• proximal mandible is slightly hypoplastic
|
|
• the palatal processes of the palatine and maxilla appear to fuse normally along the midline, although both structures are smaller
|
|
• the palatal processes of the palatine and maxilla appear to fuse normally along the midline, although both structures are smaller
|
|
• the middle-ear ossicles are either hypoplastic or absent
|
|
• the middle-ear ossicles are either hypoplastic or absent, although portions of the alisphenoid appear better developed
|
|
• distances between the lateral nasal prominences and the olfactory pits are extended at E10.5 and E11.5
|
|
• maxillary processes are symmetrically reduced in size
|
|
• nasal capsule remains unfused at E18.5
|
|
• near complete loss of the secondary palate at E18.5
|
|
• mixed penetrance of palatal shelf fusion, although clefting is fully penetrant
|
|
• E9.5 embryos exhibit decreased cell death within the pharyngeal arch mesenchyme compared to single conditional Hand1tm4Abfi heterozygotes
|
|
• at E14.5
|
|
• 100% penetrance of mid-face clefts, which are obvious at E12.5
|
digestive/alimentary system
|
• the palatal processes of the palatine and maxilla appear to fuse normally along the midline, although both structures are smaller
|
|
• the palatal processes of the palatine and maxilla appear to fuse normally along the midline, although both structures are smaller
|
|
• near complete loss of the secondary palate at E18.5
|
|
• mixed penetrance of palatal shelf fusion, although clefting is fully penetrant
|
embryo
|
• E9.5 embryos exhibit decreased cell death within the pharyngeal arch mesenchyme compared to single conditional Hand1tm4Abfi heterozygotes
|
growth/size/body
|
• the palatal processes of the palatine and maxilla appear to fuse normally along the midline, although both structures are smaller
|
|
• the palatal processes of the palatine and maxilla appear to fuse normally along the midline, although both structures are smaller
|
|
• nasal capsule remains unfused at E18.5
|
|
• near complete loss of the secondary palate at E18.5
|
|
• mixed penetrance of palatal shelf fusion, although clefting is fully penetrant
|
|
• at E14.5
|
|
• 100% penetrance of mid-face clefts, which are obvious at E12.5
|
hearing/vestibular/ear
|
• the middle-ear ossicles are either hypoplastic or absent
|
|
• the middle-ear ossicles are either hypoplastic or absent, although portions of the alisphenoid appear better developed
|
respiratory system
|
• nasal capsule remains unfused at E18.5
|
|
• at E14.5
|
skeleton
|
• squamosal bone is slightly hypoplastic
|
|
• proximal mandible is slightly hypoplastic
|
|
• the palatal processes of the palatine and maxilla appear to fuse normally along the midline, although both structures are smaller
|
|
• the palatal processes of the palatine and maxilla appear to fuse normally along the midline, although both structures are smaller
|
|
• the middle-ear ossicles are either hypoplastic or absent
|
|
• the middle-ear ossicles are either hypoplastic or absent, although portions of the alisphenoid appear better developed
|
|
• nasal capsule remains unfused at E18.5
|
