Analysis Tools
mortality/aging
craniofacial
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• absence of at least a portion of the ala temporalis portion of the alisphenoid
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• the squamosal bones are highly hypoplastic but are better formed than in compound heterozygous Hand1tm2Eno/ Hand1tm4Abfi conditional mice
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• proximal mandible appears slightly smaller
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• the premaxilla bones are highly hypoplastic but are better formed than in compound heterozygous Hand1tm2Eno/ Hand1tm4Abfi conditional mice
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• the nasal bones are highly hypoplastic but are better formed than in compound heterozygous Hand1tm2Eno/ Hand1tm4Abfi conditional mice
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• nasal capsule remains unfused at E18.5
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• palatal shelves are not fused, resulting in aberrant communication between the nasopharynx and oral cavity
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• E9.5 embryos exhibit a reduction in the developmental dorso-lateral cell death domains while showing an increase in pharyngeal arch cell death
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• tongue fails to drop at E14.5 at the time that palatal shelves fail to fuse
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• the midline cleft of the maxilla is more severe than in conditional heterozygous Hand1tm3Abfi mice, with the defect extending into the parietal bones
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digestive/alimentary system
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• palatal shelves are not fused, resulting in aberrant communication between the nasopharynx and oral cavity
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• tongue fails to drop at E14.5 at the time that palatal shelves fail to fuse
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embryo
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• E9.5 embryos exhibit a reduction in the developmental dorso-lateral cell death domains while showing an increase in pharyngeal arch cell death
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growth/size/body
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• the nasal bones are highly hypoplastic but are better formed than in compound heterozygous Hand1tm2Eno/ Hand1tm4Abfi conditional mice
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• nasal capsule remains unfused at E18.5
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• palatal shelves are not fused, resulting in aberrant communication between the nasopharynx and oral cavity
|
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• tongue fails to drop at E14.5 at the time that palatal shelves fail to fuse
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• the midline cleft of the maxilla is more severe than in conditional heterozygous Hand1tm3Abfi mice, with the defect extending into the parietal bones
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respiratory system
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• the nasal bones are highly hypoplastic but are better formed than in compound heterozygous Hand1tm2Eno/ Hand1tm4Abfi conditional mice
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• nasal capsule remains unfused at E18.5
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skeleton
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• absence of at least a portion of the ala temporalis portion of the alisphenoid
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• the squamosal bones are highly hypoplastic but are better formed than in compound heterozygous Hand1tm2Eno/ Hand1tm4Abfi conditional mice
|
|
• proximal mandible appears slightly smaller
|
|
• the premaxilla bones are highly hypoplastic but are better formed than in compound heterozygous Hand1tm2Eno/ Hand1tm4Abfi conditional mice
|
|
• the nasal bones are highly hypoplastic but are better formed than in compound heterozygous Hand1tm2Eno/ Hand1tm4Abfi conditional mice
|
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• nasal capsule remains unfused at E18.5
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