Phenotypes Associated with This Genotype

Genotype
MGI:5607953

• Allelic Composition: Plcl1^tm1.1Matk/Plcl1^tm1.1Matk
• Genetic Background: FVB.Cg-Plcl1^tm1.1Matk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increase in TPA-induced skin proliferation in Plcl1^tm1.1Matk/Plcl1^tm1.1Matk and Plcl1^tm2.1Matk/Plcl1^tm2.1Matk mice

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:207384 )

• Background Sensitivity: increased mortality in a 2-stage (DMBA and TPA) chemical skin carcinogenesis model for mice on an inbred FVB background but not in mice on a mixed C57BL/6 and FVB background

neoplasm

increased incidence of tumors by chemical induction ( J:207384 )

• increase in tumor incidence and volume in a 2-stage (DMBA and TPA) chemical skin carcinogenesis model

increased tumor growth/size ( J:207384 )

• increase in tumor volume in a 2-stage (DMBA and TPA) chemical skin carcinogenesis model

integument

epidermal hyperplasia ( J:207384 )

• higher basal proliferation rate

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:207384 )

• Background Sensitivity: increased mortality in a 2-stage (DMBA and TPA) chemical skin carcinogenesis model for mice on an inbred FVB background but not in mice on a mixed C57BL/6 and FVB background

increased incidence of tumors by chemical induction ( J:207384 )

• increase in tumor incidence and volume in a 2-stage (DMBA and TPA) chemical skin carcinogenesis model