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Phenotypes Associated with This Genotype
Genotype
MGI:5607956
Allelic
Composition		 Plcl1tm2.1Matk/Plcl1tm2.1Matk
Genetic
Background		 FVB.Cg-Plcl1tm2.1Matk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcl1tm2.1Matk mutation (0 available); any Plcl1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increase in TPA-induced skin proliferation in Plcl1tm1.1Matk/Plcl1tm1.1Matk and Plcl1tm2.1Matk/Plcl1tm2.1Matk mice

neoplasm
increased incidence of tumors by chemical induction ( J:207384 )
• increase in tumor incidence but not tumor volume in a 2-stage (DMBA and TPA) chemical skin carcinogenesis model

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:207384 )
• increase in tumor incidence but not tumor volume in a 2-stage (DMBA and TPA) chemical skin carcinogenesis model

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory