Analysis Tools
reproductive system
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• at 3 months of age the diameter of the seminiferous tubules is shorter than in controls, the lumen of the tubules are absent, and the tubules consist of predominantly Sertoli cells with occasional spermatogonia
• tubulin staining of testes cross sections shows diffuse expression of microtubules with little evidence for organization into bundles, and there is some extracellular vacuolization but to a lesser degree than that of mice homozygous for the Gt(ROSABetageo)1Sor allele
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• homozygotes have much smaller testes, on average less than 75mg where heterozygous controls have an average testes weight of over 200mg
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• although males copulate and cause vaginal plugs, they fail to impregnate females
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endocrine/exocrine glands
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• at 3 months of age the diameter of the seminiferous tubules is shorter than in controls, the lumen of the tubules are absent, and the tubules consist of predominantly Sertoli cells with occasional spermatogonia
• tubulin staining of testes cross sections shows diffuse expression of microtubules with little evidence for organization into bundles, and there is some extracellular vacuolization but to a lesser degree than that of mice homozygous for the Gt(ROSABetageo)1Sor allele
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• homozygotes have much smaller testes, on average less than 75mg where heterozygous controls have an average testes weight of over 200mg
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