Phenotypes Associated with This Genotype

Genotype
MGI:5610127

• Allelic Composition: Hrh1^Bphs-r/Hrh1^Bphs-s
• Genetic Background: (C3H/HeJ x SJL/J)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune system physiology ( J:77938 )

• mice are susceptible to experimental allergic encephalomyelitis (EAE)

• males mice are susceptible to experimental allergic orchitis (EAO)

• hypersensitivity to agents and treatments that affect the vascular bed

abnormal response to infection ( J:77938 )

increased susceptibility to bacterial infection ( J:77938 )

increased susceptibility to bacterial infection induced morbidity/mortality ( J:77938 )

• mice sensitized to Bordetella pertussis toxin (PTX) show clinical signs of induced histamine-elicited vasoactive amine sensitization (VAASH)

• death due to experimental sensitivity occurred within 30 minutes

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:77938 )

• mice sensitized to Bordetella pertussis toxin (PTX) show clinical signs of induced histamine-elicited vasoactive amine sensitization (VAASH)

• death due to experimental sensitivity occurred within 30 minutes