Phenotypes Associated with This Genotype

Genotype
MGI:5614219

• Allelic Composition: Atf6^tm1Hota/Atf6^tm1Hota; Tg(Ins2-cre)25Mgn/0
• Genetic Background: B6.Cg-Atf6^tm1Hota Tg(Ins2-cre)25Mgn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased insulin sensitivity ( J:213542 )

• slightly with lower insulin secretion curve in a glucose stimulated insulin secretion assay

decreased physiological sensitivity to xenobiotic ( J:213542 )

• increased cell death in primary islets that is not decreased in the presence of TUDCA

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:213542 )

N • beta cells develop normally

increased pancreatic islet cell apoptosis ( J:213542 )

• increased cell death in primary islets that is not decreased in the presence of TUDCA

growth/size/body

growth/size/body region phenotype ( J:213542 )

N • mice exhibit normal body weight

cellular

increased pancreatic islet cell apoptosis ( J:213542 )

• increased cell death in primary islets that is not decreased in the presence of TUDCA