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Phenotypes Associated with This Genotype
Genotype
MGI:5614220
Allelic
Composition		 Atf6tm1Hota/Atf6tm1Hota
Tg(Ins2-cre)25Mgn/0
Tg(Ins2-GP)1Kbuw/0
Genetic
Background		 involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf6tm1Hota mutation (1 available); any Atf6 mutation (45 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
Tg(Ins2-GP)1Kbuw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:213542 )
• TUDCA-treated mice fail to exhibit a protective effect from diabetes with decreased insulin content and number of apoptotic cells in islets compared wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory