Phenotypes Associated with This Genotype

Genotype
MGI:5616240

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Irx3*)Hui}/Gt(ROSA)26Sor⁺; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:208887 )

• similar to mice homozygous for Irx3^tm1Hui

adipose tissue

decreased fat cell size ( J:208887 )

• similar to mice homozygous for Irx3^tm1Hui

decreased percent body fat/body weight ( J:208887 )

• similar to mice homozygous for Irx3^tm1Hui

abnormal white adipose tissue physiology ( J:208887 )

• expression analysis indicates browning of white adipose

homeostasis/metabolism

increased energy expenditure ( J:208887 )

• similar to mice homozygous for Irx3^tm1Hui

improved glucose tolerance ( J:208887 )

• similar to mice homozygous for Irx3^tm1Hui

behavior/neurological

behavior/neurological phenotype ( J:208887 )

N • food intake and locomotor activity are similar to controls