Phenotypes Associated with This Genotype

Genotype
MGI:5632171

• Allelic Composition: Tnfsf13b^M1Btlr/Tnfsf13b⁺
• Genetic Background: C57BL/6J-Tnfsf13b^M1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell number ( J:220069 )

• decreased numbers of B cells in peripheral blood.

• reduced frequency of IgM+ B cells in the periphery.

• reduced frequency of peripheral IgD+ B cells.

increased T cell number ( J:220069 )

• in the peripheral blood.

increased single-positive T cell number ( J:220069 )

• increased frequency of CD8⁺ T cells in the periphery.

decreased IgG level ( J:220069 )

• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal).

decreased IgM level ( J:220069 )

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll).

immune system

decreased B cell number ( J:220069 )

• decreased numbers of B cells in peripheral blood.

• reduced frequency of IgM+ B cells in the periphery.

• reduced frequency of peripheral IgD+ B cells.

increased T cell number ( J:220069 )

• in the peripheral blood.

increased single-positive T cell number ( J:220069 )

• increased frequency of CD8⁺ T cells in the periphery.

decreased IgG level ( J:220069 )

• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal).

decreased IgM level ( J:220069 )

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll).

impaired humoral immune response ( J:220069 )

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll).

• diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal).