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Phenotypes Associated with This Genotype
Genotype
MGI:5632520
Allelic
Composition		 Ppiftm1Maf/Ppiftm1Maf
Tg(THY1-SNCA*A53T)M53Sud/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppiftm1Maf mutation (1 available); any Ppif mutation (18 available)
Tg(THY1-SNCA*A53T)M53Sud mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:212732 )
• although mice start to die around 36 weeks of age and all die by 60 weeks of age, survival is extended compared to single Tg(THY1-SNCA*A53T)M53Sud transgenic mice

nervous system
neurodegeneration ( J:212732 )
• mice exhibit a delay in disease onset compared to single (THY1-SNCA*A53T)M53Sud transgenic mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory