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Phenotypes Associated with This Genotype
Genotype
MGI:5634401
Allelic
Composition		 Cdh1tm2Kem/Cdh1+
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Trp53tm1Brn/Trp53tm1Brn
Tg(Vil1-cre)20Syr/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh1tm2Kem mutation (1 available); any Cdh1 mutation (173 available)
Smad4tm2.1Cxd mutation (2 available); any Smad4 mutation (47 available)
Tg(Vil1-cre)20Syr mutation (4 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (239 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased intestinal adenocarcinoma incidence ( J:212549 )
• mice develop intestinal adenocarcinomas with a median tumor-free survival of 5.2 months of age and no distant metastases are seen

digestive/alimentary system
increased intestinal adenocarcinoma incidence ( J:212549 )
• mice develop intestinal adenocarcinomas with a median tumor-free survival of 5.2 months of age and no distant metastases are seen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory