Phenotypes Associated with This Genotype

Genotype
MGI:5637745

• Allelic Composition: Gt(ROSA)26Sor^tm1(GRN)Pvd/Gt(ROSA)26Sor⁺; Tg(Pgk1-cre)1Lni/0; Tg(SOD1*G93A)1Gur/0
• Genetic Background: B6J.Cg-Tg(Pgk1-cre)1Lni Gt(ROSA)26Sor^tm1(GRN)Pvd Tg(SOD1*G93A)1Gur

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:211734 )

• average lifespan is 163.3 days

nervous system

motor neuron degeneration ( J:211734 )

• onset or progression of motor neuron degeneration is similar to that seen in mice expressing only Tg(SOD1*G93A)1Gur, with an average onset of disease at 134.2 days

behavior/neurological

impaired coordination ( J:211734 )

• mice show impaired performance on the rotarod and in hanging from a grid to a similar extent as seen in mice expressing only Tg(SOD1*G93A)1Gur