Phenotypes Associated with This Genotype

Genotype
MGI:5640744

• Allelic Composition: Jak2^tm1.2Ble/Jak2⁺; Picalm^tm1.1Tmae/Picalm^tm1.1Tmae; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hypochromic microcytic anemia ( J:220728 )

decreased erythrocyte cell number ( J:220728 )

• decreased numbers of mature erythrocytes

decreased hematocrit ( J:220728 )

decreased hemoglobin content ( J:220728 )

decreased mean corpuscular hemoglobin ( J:220728 )

decreased mean corpuscular volume ( J:220728 )

decreased CD4-positive, alpha-beta T cell number ( J:220728 )

• decreased numbers of CD4+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:220728 )

• decreased numbers of CD8+ T cells

reticulocytosis ( J:220728 )

• elevated reticulocyte counts

homeostasis/metabolism

abnormal iron homeostasis ( J:220728 )

• transferrin/transferrin receptor endocytic rate is decreased as compared to wild-type

immune system

decreased CD4-positive, alpha-beta T cell number ( J:220728 )

• decreased numbers of CD4+ T cells

decreased CD8-positive, alpha-beta T cell number ( J:220728 )

• decreased numbers of CD8+ T cells