Phenotypes for Sox10 MGI:5648383 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Sox10^gt/Sox10^tm1Weg
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * GT/Le

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10^gt mutation (0 available); any Sox10 mutation (34 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Lack of pigmentation and megacolon in Sox10^gt/Sox10^tm1Weg pups

mortality/aging

postnatal lethality, complete penetrance ( J:216967 )

• mice survive to birth but most die within 4-5 days after birth

digestive/alimentary system

megacolon ( J:216967 )

• all mice develop severe and fatal megacolon

integument

absent coat pigmentation ( J:216967 )

• mice have pigmented eyes but white fur

nervous system

brain vacuoles ( J:216967 )

pigmentation

absent coat pigmentation ( J:216967 )

• mice have pigmented eyes but white fur

decreased melanocyte number ( J:216967 )

• lack of skin melanocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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