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Phenotypes Associated with This Genotype
Genotype
MGI:5660302
Allelic
Composition		 Lats1tm1Noj/Lats1tm1Noj
Lats2tm1.1Dupa/Lats2tm1.1Dupa
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lats1tm1Noj mutation (1 available); any Lats1 mutation (52 available)
Lats2tm1.1Dupa mutation (1 available); any Lats2 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bile duct epithelium morphology ( J:223215 )
• extensive proliferation of cryokeratin-positive biliary epithelial cells observed in liver following adenovirus expressing Cre recombinase (Ad-Cre) injection

liver/biliary system
abnormal bile duct epithelium morphology ( J:223215 )
• extensive proliferation of cryokeratin-positive biliary epithelial cells observed in liver following adenovirus expressing Cre recombinase (Ad-Cre) injection
enlarged liver ( J:223215 )
• mice develop hepatomegaly 8 weeks after Ad-Cre injection
increased liver weight ( J:223215 )
• liver size reaches 30% of body weight 8 weeks after Ad-Cre injection

growth/size/body
enlarged liver ( J:223215 )
• mice develop hepatomegaly 8 weeks after Ad-Cre injection
increased liver weight ( J:223215 )
• liver size reaches 30% of body weight 8 weeks after Ad-Cre injection

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory