Phenotypes Associated with This Genotype

Genotype
MGI:5693398

• Allelic Composition: Bmi1^tm1Sgon/Bmi1^tm1Sgon; Commd10^{Tg(Vav1-icre)A2Kio}/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:221849 )

• born at the expected frequency and fertile

• 93% die by 24-26 weeks

hematopoietic system

abnormal thymus morphology ( J:221849 )

small thymus ( J:221849 )

• 4X smaller than controls in older mice

thymus atrophy ( J:221849 )

• with loss of cortico-medullary differentiation

abnormal hemopoiesis ( J:221849 )

decreased common myeloid progenitor cell number ( J:221849 )

• absolute numbers of progenitors reduced 2 fold

• reduced myeloid colony formation

abnormal erythropoiesis ( J:221849 )

• reduced erythroid colony formation

decreased bone marrow cell number ( J:221849 )

• cellularity reduced

• hypoplasia in femora

increased common lymphocyte progenitor cell number ( J:221849 )

• significant and progressive increase of immunophenotypic common lymphoid fraction

• lymphoid colony frequency is reduced 4X

• increased proportion of cells in S/G2/M phase

• homing of cells to host bone marrow is reduced

decreased B cell number ( J:221849 )

• significant loss of B lymphocytes in young mice

decreased T cell number ( J:221849 )

• significant loss of T lymphocytes in young mice

decreased myeloid cell number ( J:221849 )

• slight decrease in myeloid cells

decreased hematopoietic stem cell number ( J:221849 )

• in bone marrow

• remaining cells unable to repopulate irradiated hosts

• stem cells fail to maintain quiescence

abnormal spleen morphology ( J:221849 )

decreased spleen red pulp amount ( J:221849 )

• hypoplasia

small spleen ( J:221849 )

• 4X smaller than controls in older mice

abnormal spleen white pulp morphology ( J:221849 )

absent spleen germinal center ( J:221849 )

abnormal spleen periarteriolar lymphoid sheath morphology ( J:221849 )

• reduced size

decreased spleen white pulp amount ( J:221849 )

• hypoplasia

immune system

abnormal immune system cell morphology ( J:221849 )

decreased B cell number ( J:221849 )

• significant loss of B lymphocytes in young mice

decreased T cell number ( J:221849 )

• significant loss of T lymphocytes in young mice

abnormal immune system organ morphology ( J:221849 )

abnormal thymus morphology ( J:221849 )

small thymus ( J:221849 )

• 4X smaller than controls in older mice

thymus atrophy ( J:221849 )

• with loss of cortico-medullary differentiation

abnormal spleen morphology ( J:221849 )

decreased spleen red pulp amount ( J:221849 )

• hypoplasia

small spleen ( J:221849 )

• 4X smaller than controls in older mice

abnormal spleen white pulp morphology ( J:221849 )

absent spleen germinal center ( J:221849 )

abnormal spleen periarteriolar lymphoid sheath morphology ( J:221849 )

• reduced size

decreased spleen white pulp amount ( J:221849 )

• hypoplasia

endocrine/exocrine glands

abnormal thymus morphology ( J:221849 )

small thymus ( J:221849 )

• 4X smaller than controls in older mice

thymus atrophy ( J:221849 )

• with loss of cortico-medullary differentiation