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Phenotypes Associated with This Genotype
Genotype
MGI:5695300
Allelic
Composition		 Prkcbtilc/Prkcb+
Genetic
Background		 involves: C57BL/6JSfdAnu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcbtilc mutation (2 available); any Prkcb mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal humoral immune response ( J:221236 )
• intermediate response to TI-2 antigens between that of homozygous and wild-type mice
decreased IgG3 level ( J:221236 )
• basal levels decreased 75%
decreased IgM level ( J:221236 )
• 50% reduction in IgM levels in un-immunized heterozygous mice

hematopoietic system
decreased IgG3 level ( J:221236 )
• basal levels decreased 75%
decreased IgM level ( J:221236 )
• 50% reduction in IgM levels in un-immunized heterozygous mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory