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Phenotypes Associated with This Genotype
Genotype
MGI:5695334
Allelic
Composition
Tysnd1tm1.1Arte/Tysnd1tm1.1Arte
Genetic
Background
involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tysnd1tm1.1Arte mutation (0 available); any Tysnd1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Male Tysnd1tm1.1Arte/Tysnd1tm1.1Arte mice are infertile

reproductive system
N
• female mice produced normal litter sizes
• abnormal anterior acrosome lacking the acrosomal cap
• when the cumulus mass is intact

liver/biliary system
• in phytol in CMC-fed mice
• enlarged peroxisomes in carboxy methyl cellulose (CMC)-fed mice
• decreased number of peroxisomes and an increase in autophagosomes in the liver in phytol in CMC-fed mice
• however, mitochondria appear intact
• phytol-fed males have increased amount of total fat and triglycerides, indicating onset of fatty liver
• beige in phytol in CMC-fed mice

homeostasis/metabolism
• several plasmalogen species are reduced compared to in wild-type mice
• however, total levels are normal

behavior/neurological
• reduced home cage activity in male mice at 34 weeks

cellular
• abnormal anterior acrosome lacking the acrosomal cap

growth/size/body
• in phytol in CMC-fed mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory