Phenotypes Associated with This Genotype

Genotype
MGI:5696618

• Allelic Composition: Lepr^tm5Mgmj/Lepr^tm5Mgmj
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:221245 )

• although male body weight on a normal diet is normal, female body weight on the same diet is significantly increased

• on a high fat diet both sexes are slightly heavier than controls

adipose tissue

increased total body fat amount ( J:221245 )

• fat mass slightly increased when fed a high fat diet

homeostasis/metabolism

increased circulating leptin level ( J:221245 )

♀ • circulating leptin levels increase significantly only in females on a high fat diet

increased oxygen consumption ( J:221245 )

♂ • male oxygen consumption is elevated in both light and dark phase

behavior/neurological

increased food intake ( J:221245 )

• increase of 5-10% on a high fat diet with no increase on a normal diet

reproductive system

reproductive system phenotype ( J:221245 )

♀N • first estrus cycle proceeds normally

delayed estrus ( J:221245 )

♀ • second and later estrus cycles are delayed with interval between cycles twice as long as controls