Phenotypes Associated with This Genotype

Genotype
MGI:5697928

• Allelic Composition: Dbx1^tm2Jcor/Dbx1^tm1Tmj; Tg(Nkx2-1-cre)2Sand/0
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hypothalamus secretion ( J:221571 )

♀ • attenuated response to predator (rat) odor is observed in females ( as measured by corticosterone levels in the lateral hypothalamus area) as compared to control females

♀ • males (either control or mutant) do not exhibit a response

abnormal action potential ( J:221571 )

• slices from the lateral hypothalamic area (LH) exhibit 85% lower spike density in low glucose

• slices from the lateral hypothalamic area (LH) exhibit 50% lower average spike frequency in high glucose

• however, glucose tolerance is not affected

behavior/neurological

abnormal response to novel odor ( J:221571 )

♀ • females exhibit a similar response following presentation with either rat or benign odor in contrast to controls

♀ • females exhibit fewer and shorter escape behaviors as compared to controls following presentation with rat odor

decreased food intake ( J:221571 )

♀ • females eat less than controls on a restricted diet

decreased compensatory feeding amount ( J:221571 )

♀ • decrease in amount of food consumed following a 12 hour fast is observed in females, but not males

♀ • however, daily food consumption is similar to controls

increased locomotor activity ( J:221571 )

♂ • activity, as determined by horizontal line crossings, is increased in males, but not in females

growth/size/body

decreased body weight ( J:221571 )

• decreased body weight in males, but not females, is observed after weaning

• females exhibit a decrease in body weight under restricted or high fat diets

adipose tissue

decreased percent body fat/body weight ( J:221571 )

♂ • males exhibit decrease in body fat composition after 7 weeks on high fat diet