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Phenotypes Associated with This Genotype
Genotype
MGI:5699724
Allelic
Composition		 Smarca4tm1.2Pcn/Smarca4tm1.2Pcn
Nfatc1tm1.1(cre)Bz/Nfatc1+
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (1026 available)
Nfatc1tm1.1(cre)Bz mutation (0 available); any Nfatc1 mutation (49 available)
Smarca4tm1.2Pcn mutation (1 available); any Smarca4 mutation (111 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal semilunar valve morphology ( J:226941 )
• semilunar valves have reduced endocardial-derived mesenchyme
• 2-fold increase in EdU-incorporated mesenchymal cells, indicating increased proliferation of cushion mesenchyme

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory