Phenotypes Associated with This Genotype

Genotype
MGI:5700215

• Allelic Composition: Dysf^im/Dysf⁺; Large1^myd/Large1^myd
• Genetic Background: involves: C57BL/6 * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

myositis ( J:221523 )

• macrophage infiltration is increased in skeletal muscle

abnormal skeletal muscle fiber morphology ( J:221523 )

• albumin-positive myofibers are increased in skeletal muscle indicating deterioration of the myofiber membrane fragility

increased variability of skeletal muscle fiber size ( J:221523 )

• some mice show variation in fiber size and connective tissue infiltration

centrally nucleated skeletal muscle fibers ( J:221523 )

skeletal muscle fiber degeneration ( J:221523 )

• mice show necrotic and centrally located nucleated myofibers, indicating frequent cycles of muscle degeneration and regeneration

skeletal muscle fiber necrosis ( J:221523 )

dystrophic muscle ( J:221523 )

• some mice show advanced muscular dystrophic changes such as variation in fiber size and connective tissue infiltration

immune system

myositis ( J:221523 )

• macrophage infiltration is increased in skeletal muscle