Phenotypes Associated with This Genotype

Genotype
MGI:5701417

• Allelic Composition: Icam1^tm1Jcgr/Icam1^tm1Jcgr; Vcam1^tm1Dmil/Vcam1^tm1Dmil
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

impaired macrophage chemotaxis ( J:227109 )

• reduced recruitment of monocytes/macrophages into peritoneal cavity as compared to wild-type following IP challenge with thioglycollate

decreased cell chemotaxis ( J:227109 )

• reduced recruitment of leukocytes into peritoneal cavity as compared to wild-type and heterozygous Vcam1^tmDmil following IP challenge with ovalbumin

• numbers of monocytes, macrophages and lymphocytes recovered from the peritoneal cavity are reduced, but not neutrophils or eosinophils

hematopoietic system

impaired macrophage chemotaxis ( J:227109 )

• reduced recruitment of monocytes/macrophages into peritoneal cavity as compared to wild-type following IP challenge with thioglycollate

immune system

impaired macrophage chemotaxis ( J:227109 )

• reduced recruitment of monocytes/macrophages into peritoneal cavity as compared to wild-type following IP challenge with thioglycollate