Phenotypes Associated with This Genotype

Genotype
MGI:5703653

• Allelic Composition: Havcr2^tm1Vlcg/Havcr2^tm1Vlcg
• Genetic Background: B6.129-Havcr2^tm1Vlcg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell number ( J:209885 )

• after infection with attenuated Listeria monocytogenes expressing OVA

• CD8alpha^loCD11a^hi cells in peripheral blood and spleen are significantly reduced at 7 and 14 days after infection

• cell numbers are not significantly different from controls at later time points

• reduced cell proliferation but normal cell survival

• cell numbers reduced subsequent to secondary infection with virulent bacteria

decreased interferon-gamma secretion ( J:209885 )

• IFN-gamma producing cells are reduced at 7 and 15 days after infection and pulse with OVA

• also reduced IFN-gamma producing cells after secondary infection with virulent bacteria

hematopoietic system

decreased T cell number ( J:209885 )

• after infection with attenuated Listeria monocytogenes expressing OVA

• CD8alpha^loCD11a^hi cells in peripheral blood and spleen are significantly reduced at 7 and 14 days after infection

• cell numbers are not significantly different from controls at later time points

• reduced cell proliferation but normal cell survival

• cell numbers reduced subsequent to secondary infection with virulent bacteria