Phenotypes Associated with This Genotype

Genotype
MGI:5703835

• Allelic Composition: Syne1^tm1Chen/Syne1^tm1Chen; Syne2^tm1.1Chen/Syne2^tm1.1Chen; Tg(Nkx2-5-cre)9Eno/?
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ultrastructural nuclear abnormalities in Syne1^tm1Chen/Syne1^tm1Chen Syne2^tm1.1ChenSyne2^tm1.1Chen Tg(Nkx2-5-cre)9Eno/? cardiomyocytes

cardiovascular system

cardiovascular system phenotype ( J:211007 )

N • heart rate remains unchanged through course of study

abnormal heart morphology ( J:211007 )

abnormal heart weight ( J:211007 )

• significant increase in heart weight/body weight and heart weight/total length ratios at 10 weeks of age

thin ventricular wall ( J:211007 )

• wall thinning observed at 10 weeks but not at 5 weeks of age

• thinning continues through 25 and 52 weeks

cardiac fibrosis ( J:211007 )

• at 10 weeks

abnormal cardiovascular system physiology ( J:211007 )

decreased cardiac muscle contractility ( J:211007 )

• diminished fractional shortening at 10 weeks but not 5 weeks of age

• fractional shortening continues to decline at 25 and 52 weeks

cellular

abnormal cell nucleus morphology ( J:211007 )

• nuclei are considerably enlarged and binuclei are closer together

• nuclei are less circular

• nuclear abnormalities begin to appear at 1 day of age

increased cardiomyocyte apoptosis ( J:211007 )

• at 10 weeks of age

muscle

decreased cardiac muscle contractility ( J:211007 )

• diminished fractional shortening at 10 weeks but not 5 weeks of age

• fractional shortening continues to decline at 25 and 52 weeks

increased cardiomyocyte apoptosis ( J:211007 )

• at 10 weeks of age