Phenotypes Associated with This Genotype

Genotype
MGI:5703894

• Allelic Composition: Smc2^tm1.1Hiran/Smc2^tm1.2Hiran; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell nucleus morphology ( J:222181 )

• hyperclustering of chromocenters in neurons

abnormal mitosis ( J:222181 )

• mice exhibit postmitotic cells with tail-like structures, indicative of defective chromosome segregation

• mitotic chromosomes are highly disorganized at prometaphase in 88.6% of cells

• hyperclustering of chromocenters (the nuclear structure that forms from the association of pericentric heterochromatin from several different chromosomes during interphase) in neurons

nervous system

abnormal cerebral cortex morphology ( J:222181 )

• cerebral cortices are disorganized at E16.5 and no recognizable cortex is seen by E19.5

thin cerebral cortex ( J:222181 )

• cerebral cortices are extremely thin at E16.5

abnormal neuronal stem cell morphology ( J:222181 )

• Sox2+ neural stem cells largely disappear

decreased neuron number ( J:222181 )

• neurons in the cortical plate are reduced at E16.5

• Brn2+ upper-layer (later born) neurons are depleted more severly than the Tbr1+ deep-layer (early born) neurons

abnormal neuronal stem cell physiology ( J:222181 )

• neural stem cells cultures show cells with limited proliferation capacities as seen by decreased neurosphere formation and cell population sizes