Phenotypes Associated with This Genotype

Genotype
MGI:5704372

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Trp53^tm2Tyj/Trp53⁺; Amhr2^tm3(cre)Bhr/Amhr2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased granulosa cell tumor incidence ( J:222579 )

♀ • 70% of mice develop granulosa-cell tumors in the ovary

increased ovarian carcinoma incidence ( J:222579 )

♀ • 30% of mice develop high-grade serous carcinoma originating in the ovary

♀ • however, mice do not develop serous carcinomas originating from the fallopian tube

increased metastatic potential ( J:222579 )

♀ • serous carcinoma spreads throughout the peritoneal cavity, to the omentum and across the peritoneal membrane, including the mesentery and diaphragm

mortality/aging

premature death ( J:222579 )

♀ • median survival is 11.2 months of age, with mice dying between 7.6 and 15.3 months of age

homeostasis/metabolism

ascites ( J:222579 )

♀

reproductive system

increased granulosa cell tumor incidence ( J:222579 )

♀ • 70% of mice develop granulosa-cell tumors in the ovary

increased ovarian carcinoma incidence ( J:222579 )

♀ • 30% of mice develop high-grade serous carcinoma originating in the ovary

♀ • however, mice do not develop serous carcinomas originating from the fallopian tube

endocrine/exocrine glands

increased granulosa cell tumor incidence ( J:222579 )

♀ • 70% of mice develop granulosa-cell tumors in the ovary

increased ovarian carcinoma incidence ( J:222579 )

♀ • 30% of mice develop high-grade serous carcinoma originating in the ovary

♀ • however, mice do not develop serous carcinomas originating from the fallopian tube

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ovarian cancer		DOID:2394	OMIM:167000 OMIM:607893	J:222579