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Phenotypes Associated with This Genotype
Genotype
MGI:5705080
Allelic
Composition		 Ddhd1tm1.1Katn/Ddhd1tm1.1Katn
Genetic
Background		 involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddhd1tm1.1Katn mutation (2 available); any Ddhd1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ddhd1tm1.1Katn/Ddhd1tm1.1Katn spermatozoa are bent at the junction of the middle and principal pieces

cellular
teratozoospermia ( J:212425 )
• sperm bent into a hairpin-like structure
• bend located between the middle and principal pieces
• annulus not attached to the mitochondrial sheath which is shortened
• mitochondria are disorganized
• shape change occures as the sperm pass from the testis to the cauda of the epididymis
abnormal sperm annulus morphology ( J:212425 )
• annulus not attached to the mitochondrial sheath which is shortened
abnormal sperm mitochondrial sheath morphology ( J:212425 )
• mitochondria are disorganized
decreased sperm mitochondrial sheath size ( J:212425 )
• mitochondrial sheath is shortened
kinked sperm flagellum ( J:212425 )
• flagellum is bent between the middle and principal piece
asthenozoospermia ( J:212425 )
• 90% of sperm with impaired movement

reproductive system
teratozoospermia ( J:212425 )
• sperm bent into a hairpin-like structure
• bend located between the middle and principal pieces
• annulus not attached to the mitochondrial sheath which is shortened
• mitochondria are disorganized
• shape change occures as the sperm pass from the testis to the cauda of the epididymis
abnormal sperm annulus morphology ( J:212425 )
• annulus not attached to the mitochondrial sheath which is shortened
abnormal sperm mitochondrial sheath morphology ( J:212425 )
• mitochondria are disorganized
decreased sperm mitochondrial sheath size ( J:212425 )
• mitochondrial sheath is shortened
kinked sperm flagellum ( J:212425 )
• flagellum is bent between the middle and principal piece
asthenozoospermia ( J:212425 )
• 90% of sperm with impaired movement
decreased testis weight ( J:212425 )
• modestly reduced
reduced male fertility ( J:212425 )
• males are subfertile
• much smaller litters are produced
• reduction in production of pregnancies

endocrine/exocrine glands
decreased testis weight ( J:212425 )
• modestly reduced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory