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Phenotypes Associated with This Genotype
Genotype
MGI:5706798
Allelic
Composition
E2f4tm2.1Lees/E2f4tm2.1Lees
E2f5tm1Dli/E2f5+
Tg(Vil1-cre)20Syr/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f4tm2.1Lees mutation (1 available); any E2f4 mutation (21 available)
E2f5tm1Dli mutation (1 available); any E2f5 mutation (13 available)
Tg(Vil1-cre)20Syr mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• male mice exhibit normal spermatogenesis
• often contains many spermatozoa
• with dilation at that the expense of the epithelium
• spermatozoa accumulate in the efferent ducts unlike in wild-type mice
• efferent duct epithelium lacks multiciliated cells and exhibit decreased abundance of endocytic vesicle apparatus
• no spermatozoa are detected in the epididymis

endocrine/exocrine glands
• often contains many spermatozoa
• with dilation at that the expense of the epithelium


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory