Phenotypes Associated with This Genotype

Genotype
MGI:5749806

• Allelic Composition: Tg(Adipoq-LPL)1Fnln/?
• Genetic Background: B6.Cg-Tg(Adipoq-LPL)1Fnln

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased food intake ( J:226970 )

• increase in net food intake in calorimetry chamber is observed in mice after 12 weeks on high fat diet

growth/size/body

increased body weight ( J:226970 )

• increase in weight after 24 hours in calorimetry chamber is observed in mice after 12 weeks on high fat diet

• however, body weight at the end of the study is slightly, but not significantly, decreased as compared to controls

decreased susceptibility to diet-induced obesity ( J:226970 )

♂

homeostasis/metabolism

decreased fasting circulating glucose level ( J:226970 )

♂ • is observed in male mice on high fat diet (60%) as compared to controls

decreased circulating cholesterol level ( J:226970 )

♂ • decreased serum cholesterol in males fed high fat diet

decreased circulating HDL cholesterol level ( J:226970 )

♂ • decreased HDL in males fed high fat diet

decreased circulating LDL cholesterol level ( J:226970 )

♂ • decreased LDL in males fed high fat diet

increased energy expenditure ( J:226970 )

• increased resting energy expenditure is observed in mice on high fat diet

• increase is not due to increased activity

decreased susceptibility to diet-induced obesity ( J:226970 )

♂

improved glucose tolerance ( J:226970 )

♂ • improved glucose tolerance is observed in male mice on high fat diet (60%) as compared to controls

♂ • females exhibit a trend for improved tolerance

increased insulin sensitivity ( J:226970 )

♂ • improved insulin tolerance is observed in male mice on high fat diet (60%)

increased circulating adiponectin level ( J:226970 )

♂ • increased serum adiponectin in males fed high fat diet

decreased liver triglyceride level ( J:226970 )

♂ • triglycerides are reduced in VLDL fraction of sera analyzed by FPLC chromatography

increased liver triglyceride level ( J:226970 )

♂ • males fed high fat diet exhibit a trend for increased liver triglycerides

♂ • however, total triglyceride levels are similar to controls

liver/biliary system

decreased liver triglyceride level ( J:226970 )

♂ • triglycerides are reduced in VLDL fraction of sera analyzed by FPLC chromatography

increased liver triglyceride level ( J:226970 )

♂ • males fed high fat diet exhibit a trend for increased liver triglycerides

♂ • however, total triglyceride levels are similar to controls