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Phenotypes Associated with This Genotype
Genotype
MGI:5751502
Allelic
Composition		 Shhtm1Chg/Shh+
Vps25m1Lis/Vps25m1Lis
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shhtm1Chg mutation (2 available); any Shh mutation (48 available)
Vps25m1Lis mutation (0 available); any Vps25 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
mandible hypoplasia ( J:223082 )
• as in Vps25m1Lis homozygotes
short snout ( J:223082 )
• stunted as in Vps25m1Lis homozygotes
abnormal outer ear morphology ( J:223082 )
• as in Vps25m1Lis homozygotes

growth/size/body
short snout ( J:223082 )
• stunted as in Vps25m1Lis homozygotes
abnormal outer ear morphology ( J:223082 )
• as in Vps25m1Lis homozygotes

limbs/digits/tail
polydactyly ( J:223082 )
• partial rescue of polydactyly observed in Vps25m1Lis homozygotes

skeleton
mandible hypoplasia ( J:223082 )
• as in Vps25m1Lis homozygotes

hearing/vestibular/ear
abnormal outer ear morphology ( J:223082 )
• as in Vps25m1Lis homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory