Phenotypes Associated with This Genotype

Genotype
MGI:5752573

• Allelic Composition: Scyl2^tm1.1Spel/Scyl2^tm1.1Spel; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:225808 )

• just over half of mice die within 24 h of birth due to malnutrition

reproductive system

priapism ( J:225808 )

• in mice that survive beyond the neonatal period

nervous system

increased neuron apoptosis ( J:225808 )

• of pyramidal CA3 neurons at P4.5, P6.5 and P8.5

• in the granular layer of the cerebellum of P6.5

microgliosis ( J:225808 )

• in the CA3 region

decreased brain size ( J:225808 )

decreased dentate gyrus size ( J:225808 )

• decreased cellularity by P14.5 and P21.5

decreased hippocampus pyramidal cell number ( J:225808 )

• near complete absence of pyramidal CA3 neurons beginning between P6.5 and P8.5

hippocampal neuron degeneration ( J:225808 )

• near complete absence of pyramidal CA3 neurons

• however, CA3 neuron loss is prevented by treatment with MK-801, an irreversible NMDA receptor antagonist

small hippocampus ( J:225808 )

• however, the CA1 region is normal in cellularity

astrocytosis ( J:225808 )

• in the CA3 region

abnormal excitatory postsynaptic potential ( J:225808 )

• decreased field excitatory postsynaptic potential in hippocampal slices

behavior/neurological

abnormal behavior ( J:225808 )

• sensory-motor deficits and abnormal behaviors in mice that survive beyond the neonatal period

abnormal depression-related behavior ( J:225808 )

• depression-like behavior (lower latency to immobility in a tail suspension test) in mice that survive beyond the neonatal period

• however, time spent immobile is normal

limb grasping ( J:225808 )

• in mice that survive beyond the neonatal period

tremors ( J:225808 )

• in mice that survive beyond the neonatal period

decreased grip strength ( J:225808 )

• detected using an inverted cage grid in mice that survive beyond the neonatal period

growth/size/body

decreased body weight ( J:225808 )

• detected at 2 weeks in mice that survive beyond the neonatal period

postnatal growth retardation ( J:225808 )

• detected at 2 weeks in mice that survive beyond the neonatal period

hematopoietic system

microgliosis ( J:225808 )

• in the CA3 region

cellular

increased neuron apoptosis ( J:225808 )

• of pyramidal CA3 neurons at P4.5, P6.5 and P8.5

• in the granular layer of the cerebellum of P6.5

immune system

microgliosis ( J:225808 )

• in the CA3 region