Phenotypes Associated with This Genotype

Genotype
MGI:5754723

• Allelic Composition: Tg(ACTB-Edn1)721Clou/0; E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺
• Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

basisphenoid bone hypoplasia ( J:221133 )

• basisphenoid bone is hypoplastic in the duplicated mandible

abnormal Meckel's cartilage morphology ( J:221133 )

• duplication of Meckel's cartilage in the duplicated mandible

abnormal temporal bone squamous part morphology ( J:221133 )

• the squamosal bone is deformed in the duplicated mandible

abnormal mandible morphology ( J:221133 )

• the duplicated mandible contains a duplicated Meckels cartilage, absent jugal and palatine bones, deformed squamosal bones, a hypoplastic basisphenoid bone and a palatal cleft

upper jaw to lower jaw transformation ( J:221133 )

• transformation of the maxilla into a mandible-like structure that is fused with the mandible

absent palatine bone ( J:221133 )

• palatine bone is absent in the duplicated mandible

absent zygomatic bone ( J:221133 )

• jugal bone is absent in the duplicated mandible

cleft palate ( J:221133 )

midline facial cleft ( J:221133 )

• mice exhibit a large mid-facial cleft

digestive/alimentary system

cleft palate ( J:221133 )

growth/size/body

cleft palate ( J:221133 )

midline facial cleft ( J:221133 )

• mice exhibit a large mid-facial cleft

skeleton

basisphenoid bone hypoplasia ( J:221133 )

• basisphenoid bone is hypoplastic in the duplicated mandible

abnormal Meckel's cartilage morphology ( J:221133 )

• duplication of Meckel's cartilage in the duplicated mandible

abnormal temporal bone squamous part morphology ( J:221133 )

• the squamosal bone is deformed in the duplicated mandible

abnormal mandible morphology ( J:221133 )

• the duplicated mandible contains a duplicated Meckels cartilage, absent jugal and palatine bones, deformed squamosal bones, a hypoplastic basisphenoid bone and a palatal cleft

upper jaw to lower jaw transformation ( J:221133 )

• transformation of the maxilla into a mandible-like structure that is fused with the mandible

absent palatine bone ( J:221133 )

• palatine bone is absent in the duplicated mandible

absent zygomatic bone ( J:221133 )

• jugal bone is absent in the duplicated mandible