Phenotypes Associated with This Genotype

Genotype
MGI:5770657

• Allelic Composition: Scube2^tm1.1Rbya/Scube2^tm1.1Rbya
• Genetic Background: B6.129-Scube2^tm1.1Rbya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:226676 )

♂

decreased body weight ( J:226676 )

♂

decreased body height ( J:226676 )

♂ • mice are shorter at birth and shorter stature is seen at weaning and persists into adulthood

decreased body length ( J:226676 )

♂ • reduction in nose-to-anus body length

limbs/digits/tail

short femur ( J:226676 )

♂

short tibia ( J:226676 )

♂

skeleton

decreased chondrocyte proliferation ( J:226676 )

♂ • chondrocyte proliferation in the tibiae is reduced

short femur ( J:226676 )

♂

short tibia ( J:226676 )

♂

decreased volumetric bone mineral density ( J:226676 )

♂ • 22% reduction of trabecular volumetric bone mineral density

decreased compact bone thickness ( J:226676 )

♂ • reduction in cortical thickness in the metaphyseal regions of distal femur and proximal tibia, with an 18% reduction in cross-sectional cortical thickness

decreased osteoblast cell number ( J:226676 )

♂ • ALP-positive osteoblast cell number is reduced whereas TRAP-positive osteoclast number remains unaltered in trabecular bone on neonatal tibias

abnormal trabecular bone morphology ( J:226676 )

♂ • lower trabecular bone in the metaphyseal regions of distal femur and proximal tibia

decreased trabecular bone volume ( J:226676 )

♂ • 41% reduction in trabecular bone volume

decreased bone trabecula number ( J:226676 )

♂ • 33% reduction in trabecular number

decreased trabecular bone thickness ( J:226676 )

♂ • 15% reduction in trabecular thickness

abnormal skeleton development ( J:226676 )

♂ • skeletogenesis is abnormal, with all appendicular (the upper and lower limbs) and axial (the skull, the vertebral column, and the rib cage) skeletal elements smaller

♂ • bone marrow mesenchymal stromal cells cultured in osteogenic differentiation media show impeded osteogenic differentiation

abnormal long bone epiphyseal plate proliferative zone ( J:226676 )

♂ • 20% reduction in the length of the proliferative chondrocyte zone of growth plates

abnormal long bone hypertrophic chondrocyte zone ( J:226676 )

♂ • 15% reduction in the length of the hypertrophic chondrocyte zone of growth plates

abnormal chondrocyte differentiation ( J:226676 )

♂ • embryonic limb mesenchymal cells show decreased chondrogenic differentiation in culture

abnormal bone ossification ( J:226676 )

♂ • lower dynamic bone formation rate

abnormal endochondral bone ossification ( J:226676 )

♂ • compromised endochondrial ossification

cellular

decreased chondrocyte proliferation ( J:226676 )

♂ • chondrocyte proliferation in the tibiae is reduced