Analysis Tools
nervous system
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• at 14-19 weeks of age, the synaptosomal glutamate uptake capacity (Vmax) is reduced by ~40% relative to wild-type controls
• uptake of D-[3H]aspartate into crude forebrain synaptosomes is reduced by ~49% relative to controls
• however, both the GLT-1 protein and glutamate uptake activity that could be solubilized and reconstituted in liposomes are unaffected
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mortality/aging
| N |
• mice exhibit normal survival up to 70 weeks of age
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growth/size/body
| N |
• mice exhibit normal weight gain up to 24 weeks of age
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behavior/neurological
| N |
• at 12-52 weeks of age, mice show no significant differences in total SHIRPA scores relative to control mice
• no spontaneous clinical seizures are observed
• no electrographic seizures are detected by scalp or tethered EEG recordings
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