Phenotypes Associated with This Genotype

Genotype
MGI:5775156

• Allelic Composition: Ppp6c^tm1Shma/Ppp6c^tm1Shma; Tg(KRT14-cre/ERT)20Efu/0
• Genetic Background: involves: C57BL/6 * CBA * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

decreased subcutaneous adipose tissue amount ( J:231809 )

• in tamoxifen- and DMBA-treated mice

increased susceptibility to chemically induced skin inflammation ( J:231809 )

• cellular infiltration of the dermis in tamoxifen- and DMBA-treated mice

hyperkeratosis ( J:231809 )

• in tamoxifen- and DMBA-treated mice

thick epidermis ( J:231809 )

• in tamoxifen- and DMBA-treated mice

neoplasm

increased incidence of tumors by chemical induction ( J:231809 )

• tamoxifen-treated mice subjected to a DMBA and TPA skin cancer model exhibit earlier papilloma development compared with control mice

• tamoxifen-treated mice subjected to a DMBA and OA skin cancer model exhibit earlier papilloma development with a slight increase in tumor number compared with control mice

• tamoxifen-treated mice painted with DMBA exhibit increased skin tumor (hyperkeratotic papillomas, early follicular papilloma,exophytic papilloma, mixed papilloma, and fibropapilloma) formation compared with control mice

• however, the total number of tumors is not affected in the DMBA/TPA model

adipose tissue

decreased subcutaneous adipose tissue amount ( J:231809 )

• in tamoxifen- and DMBA-treated mice

immune system

increased susceptibility to chemically induced skin inflammation ( J:231809 )

• cellular infiltration of the dermis in tamoxifen- and DMBA-treated mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:231809 )

• tamoxifen-treated mice subjected to a DMBA and TPA skin cancer model exhibit earlier papilloma development compared with control mice

• tamoxifen-treated mice subjected to a DMBA and OA skin cancer model exhibit earlier papilloma development with a slight increase in tumor number compared with control mice

• tamoxifen-treated mice painted with DMBA exhibit increased skin tumor (hyperkeratotic papillomas, early follicular papilloma,exophytic papilloma, mixed papilloma, and fibropapilloma) formation compared with control mice

• however, the total number of tumors is not affected in the DMBA/TPA model