Phenotypes Associated with This Genotype

Genotype
MGI:5780098

• Allelic Composition: Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig; Tg(Tnnt2-cre)5Blh/0
• Genetic Background: B6.Cg-Kmt2d^tm1.1Kaig Tg(Tnnt2-cre)5Blh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:229890 )

• while present at E13.5, mice die by E14.5

cardiovascular system

cardiovascular system phenotype ( J:229890 )

N • mice exhibit normal septation of outflow tract into the aorta and pulmonary artery

thin myocardium compact layer ( J:229890 )

• at E13.5

abnormal interventricular septum morphology ( J:229890 )

• disorganized

abnormal fetal cardiomyocyte physiology ( J:229890 )

• at E11.5, ventricular myocytes exhibit prolonged waveforms of calcium transients compared with control cells

decreased fetal cardiomyocyte proliferation ( J:229890 )

cellular

decreased fetal cardiomyocyte proliferation ( J:229890 )

muscle

thin myocardium compact layer ( J:229890 )

• at E13.5

decreased fetal cardiomyocyte proliferation ( J:229890 )