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Phenotypes Associated with This Genotype
Genotype
MGI:5789013
Allelic
Composition		 Aknatm2Mak/Aknatm2Mak
Genetic
Background		 B6.129-Aknatm2Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aknatm2Mak mutation (0 available); any Akna mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to fungal infection ( J:233952 )
• increased susceptibility to infection with C. albicans
• mice exhibit substantial neutrophil infiltration, airspace enlargement followed by death

mortality/aging
postnatal lethality, incomplete penetrance ( J:233952 )
• most mice do not survive beyond 10 days of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory